Journal: Journal of Advanced Research

Article Title: S100B induces angiogenesis via the clathrin/FOXO1/β-catenin signaling pathway and contributes to Bevacizumab resistance in epithelial ovarian cancer

doi: 10.1016/j.jare.2025.05.060

Figure Lengend Snippet: The S100B inhibitor pentamidine in combination with BEV improves the ovarian cancer response compared to BEV alone. (A) Flowchart of the in vivo experiment. Two weeks after intraperitoneal inoculation of ovarian cancer cells, drug treatment was administered. The mice were randomly divided into a normal saline treatment control group, BEV treatment group, pentamidine treatment group, and BEV with pentamidine treatment group. (B) Line chart of the tumor fluorescence intensity of the four groups of mice. (C) Tumor fluorescence imaging of mice after tumor formation (week 2), after killing the control group and pentamidine treatment group (week 4–6), after killing the BEV treatment group (week 8–9), and after killing the BEV with pentamidine treatment group (week 13–14). (D) Kaplan–Meier survival curves of the four groups of mice. (E) CD31 immunohistochemical staining and (F) MVD statistics of tumor tissue from the four groups of mice. (E) S100B immunohistochemical staining and S100B (G) staining intensity of tumor tissue from the four groups of mice. BEV: Bevacizumab; MVD: Micro-vessel density; *: P < 0.05; **: P < 0.01;^: P < 0.05 vs. NC; #: P < 0.05 vs. pentamidine; &: P < 0.05 vs. BEV.

Article Snippet: The pentamidine treatment group was administered pentamidine (Selleck, China) at a dosage of 10 mg/kg intraperitoneally three times a week [ ].

Techniques: In Vivo, Saline, Control, Fluorescence, Imaging, Immunohistochemical staining, Staining

Journal: Journal of Pharmaceutical Health Care and Sciences

Article Title: Biphasic dysglycemia induced by pentamidine and detected by intermittently scanned continuous glucose monitoring: a case report of a possible drug-drug interaction with clopidogrel and literature review

doi: 10.1186/s40780-026-00549-3

Figure Lengend Snippet: Chest computed tomography (CT) findings before and after treatment. ( A ) Pre-treatment (day 1): CT shows bilateral ground-glass opacities. ( B ) Post-treatment (day 21): following treatment with sulfamethoxazole-trimethoprim and pentamidine, the opacities have improved, with residual post-inflammatory changes

Article Snippet: Given the potential risk of developing glucose dysregulation associated with pentamidine, isCGM (FreeStyle Libre; Abbott Diabetes Care, Alameda, CA, USA) was implemented based on the advice of an endocrinologist, in accordance with institutional ethical guidelines and with approval from the institutional review board.

Techniques: Computed Tomography

Journal: Journal of Pharmaceutical Health Care and Sciences

Article Title: Biphasic dysglycemia induced by pentamidine and detected by intermittently scanned continuous glucose monitoring: a case report of a possible drug-drug interaction with clopidogrel and literature review

doi: 10.1186/s40780-026-00549-3

Figure Lengend Snippet: Time course of glucose concentrations during pentamidine treatment. The X-axis represents days, and the Y-axis represents glucose concentration (mg/dL). The dashed lines indicate the thresholds for hypoglycemia (70 mg/dL) and hyperglycemia (400 mg/dL). The arrow indicates the timepoint at which oral administration of 10 g doses of glucose was initiated. Yellow circles represent interstitial glucose concentrations measured by isCGM, and red circles represent glucose concentrations measured by venous blood sampling. Abbreviation: isCGM, intermittently scanned continuous glucose monitoring; mPSL, methylprednisolone; PM, pentamidine; PSL, prednisolone; VBG, venous blood glucose

Article Snippet: Given the potential risk of developing glucose dysregulation associated with pentamidine, isCGM (FreeStyle Libre; Abbott Diabetes Care, Alameda, CA, USA) was implemented based on the advice of an endocrinologist, in accordance with institutional ethical guidelines and with approval from the institutional review board.

Techniques: Concentration Assay, Sampling

Journal: Journal of Pharmaceutical Health Care and Sciences

Article Title: Biphasic dysglycemia induced by pentamidine and detected by intermittently scanned continuous glucose monitoring: a case report of a possible drug-drug interaction with clopidogrel and literature review

doi: 10.1186/s40780-026-00549-3

Figure Lengend Snippet: Time course of glucose concentrations after pentamidine discontinuation. The X-axis represents days, and the Y-axis represents glucose concentration (mg/dL). The dashed lines indicate the thresholds for hypoglycemia (70 mg/dL) and hyperglycemia (400 mg/dL). The arrow indicates the timepoint at which oral administration of 10 g doses of glucose was initiated. Yellow circles represent interstitial glucose concentrations measured by isCGM, blue circles represent capillary blood glucose concentrations measured by point-of-care testing, and red circles represent glucose concentrations measured by venous blood sampling. Abbreviation: CBG, capillary blood glucose; isCGM, intermittently scanned continuous glucose monitoring; PSL, prednisolone; RI, regular insulin; VBG, venous blood glucose

Article Snippet: Given the potential risk of developing glucose dysregulation associated with pentamidine, isCGM (FreeStyle Libre; Abbott Diabetes Care, Alameda, CA, USA) was implemented based on the advice of an endocrinologist, in accordance with institutional ethical guidelines and with approval from the institutional review board.

Techniques: Concentration Assay, Sampling

Journal: ACS Omega

Article Title: Quantification of Interactions between Small Molecules and RNA Probes Representative of Myotonic Dystrophy Type 1 Using Affinity Capillary Electrophoresis and UPLC-UV

doi: 10.1021/acsomega.5c09840

Figure Lengend Snippet: Structure of pentamidine.

Article Snippet: LB broth, DEPC, HEPES and HEPES molecular biology grade, EDTA of molecular biology grade, MOPS, formaldehyde of molecular biology grade, pentamidine isethionate, chloroquine diphosphate, neomycin sulfate, and poly (ethylene oxide) 200k were bought from Merck.

Techniques: